Browsing by Author "Mashanova, Alla"

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    Protection versus pathology in aviremic and high viral load HIV-2 infection—The pivotal role of immune activation and T-cell kinetics
    (University of Chicago Press / Oxford University Press, 2014-05-05) Hegedus, Andrea; Nyamweya, Samuel; Zhang, Yan; Govind, Sheila; Aspinall, Richard; Mashanova, Alla; Jansen, Vincent A. A.; Whittle, Hilton; Jaye, Assan; Flanagan, Katie L.; Macallan, Derek C.
    Background. Many human immunodeficiency virus (HIV)–2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would be critical determinants of non-progressor/progressor status. Methods. We studied 37 subjects in The Gambia, West Africa: 10 HIV-negative controls, 10 HIV-2-infected subjects with low viral loads (HIV-2-LV), 7 HIV-2-infected subjects with high viral loads (HIV-2-HV), and 10 with HIV-1 infection. We measured in vivo T-cell turnover using deuterium-glucose labeling, and correlated results with T-cell phenotype (by flow cytometry) and T-cell receptor excision circle (TREC) abundance. Results. Immune activation (HLA-DR/CD38 coexpression) differed between groups with a significant trend: controls