Hegedus, AndreaNyamweya, SamuelZhang, YanGovind, SheilaAspinall, RichardMashanova, AllaJansen, Vincent A. A.Whittle, HiltonJaye, AssanFlanagan, Katie L.Macallan, Derek C.2016-02-172016-02-172014-05-05Hegedus A, Nyamweya S, Zhang Y, et al., (2014) Protection versus pathology in aviremic and high viral load HIV-2 infection—The pivotal role of immune activation and T-cell kinetics. Journal of Infectious Diseases, Volume 210, Issue 5, September 2014, pp. 752-7610022-1899http://dx.doi.org/10.1093/infdis/jiu165https://dspace.lib.cranfield.ac.uk/handle/1826/9703Background. Many human immunodeficiency virus (HIV)–2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would be critical determinants of non-progressor/progressor status. Methods. We studied 37 subjects in The Gambia, West Africa: 10 HIV-negative controls, 10 HIV-2-infected subjects with low viral loads (HIV-2-LV), 7 HIV-2-infected subjects with high viral loads (HIV-2-HV), and 10 with HIV-1 infection. We measured in vivo T-cell turnover using deuterium-glucose labeling, and correlated results with T-cell phenotype (by flow cytometry) and T-cell receptor excision circle (TREC) abundance. Results. Immune activation (HLA-DR/CD38 coexpression) differed between groups with a significant trend: controls <HIV-2-LV <HIV-1 <HIV-2-HV (P < .01 for all cell types). A similar trend was observed in the pattern of in vivo turnover of memory CD4+ and CD8+ T-cells and TREC depletion in naive CD4+ T-cells, although naive T-cell turnover was relatively unaffected by either infection. T-cell turnover, immune activation, and progressor status were closely associated. Conclusions. HIV-2 non-progressors have low rates of T-cell turnover (both CD4+ and CD8+) and minimal immune activation; high viral load HIV-2 progressors had high values, similar to or exceeding those in HIV-1 infection.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/CD4CD8HIV-2HIV-1HIV pathogenesisimmune activationimmune memoryT-cellArticle