Tiwari, Bikash RanjanBhar, RajarshiDubey, Brajesh KumarMaity, Sunil K.Brar, Satinder KaurKumar, GopalakrishnanKumar, Vinod2023-06-152023-06-152023-05-22Tiwari BR, Bhar R, Dubey BK, et al., (2023) Life cycle assessment of microbial 2,3-butanediol production from brewer’s spent grain modeled on pinch technology. ACS Sustainable Chemistry and Engineering, Volume 11, Issue 22, June 2023, pp. 8271-82802168-0485https://doi.org/10.1021/acssuschemeng.3c00616https://dspace.lib.cranfield.ac.uk/handle/1826/19778Microbial production of 2,3-butanediol (BDO) has received considerable attention as a promising alternate to fossil-derived BDO. In our previous work, BDO concentration >100 g/L was accumulated using brewer’s spent grain (BSG) via microbial routes which was followed by techno-economic analysis of the bioprocess. In the present work, a life cycle assessment (LCA) was conducted for BDO production from the fermentation of BSG to identify the associated environmental impacts. The LCA was based on an industrial-scale biorefinery processing of 100 metric tons BSG per day modeled using ASPEN plus integrated with pinch technology, a tool for achieving maximum thermal efficiency and heat recovery from the process. For the cradle-to-gate LCA, the functional unit of 1 kg of BDO production was selected. One-hundred-year global warming potential of 7.25 kg CO2/kg BDO was estimated while including biogenic carbon emission. The pretreatment stage followed by the cultivation and fermentation contributed to the maximum adverse impacts. Sensitivity analysis revealed that a reduction in electricity consumption and transportation and an increase in BDO yield could reduce the adverse impacts associated with microbial BDO production.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/2,3-Butanediolbrewer’s spent grainglobal warminglife cycle assessmentsensitivity analysisbiorefineryArticle