Bridge, KerryDavis, FrankCollyer, Stuart D.Higson, Seamus P. J.2011-10-112011-10-112007-01-01Kerry Bridge, Frank Davis, Stuart Collyer, Séamus P. J. Higson; Flexible Ultrathin PolyDVB/EVB Composite Membranes for the Optimization of a Whole Blood Glucose Sensor. Electroanalysis, 2007, Volume 19, Issue 4 , Pages 487 - 4951040-0397http://dx.doi.org/10.1002/elan.200603754http://dspace.lib.cranfield.ac.uk/handle/1826/2355An ultrathin composite membrane has been developed as the outer covering barrier in a model amperometric glucose oxidase enzyme electrode. The membrane was formed by cathodic electropolymerization of divinylbenzene/ethylvinylbenzene at the surface of a gold coated polyester support membrane. Permeability coefficients were determined for O2 and glucose across membranes with a range of polymer thicknesses. Anionic interferents (such as ascorbate), were screened from the working electrode via a charge exclusion mechanism. The enzyme electrode showed an initial 10% signal drift when first exposed to whole human blood over a period of 2 hours, after which responses remained essentially stable. Whole blood patient glucose determinations yielded a correlation coefficient of r2=0.99 compared to standard hospital analyses.en-UKCathodic electropolymerizationComposite membraneAmperometric enzyme electrodePolydivinylbenzeneBloodArticle