Chitosan–hydroxyapatite composite biomaterials made by a one step co-precipitation method: preparation, characterization and in vivo tests

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dc.contributor.authorDanilchenko, S. N.
dc.contributor.authorKalinkevich, O. V.
dc.contributor.authorPogorelov, M. V.
dc.contributor.authorKalinkevich, A. N.
dc.contributor.authorSklyar, A. M.
dc.contributor.authorKalinichenko, T. G.
dc.contributor.authorIlyashenko, V. Y.
dc.contributor.authorStarikov, V. V.
dc.contributor.authorBumeyster, V. I.
dc.contributor.authorSikora, V. Z.
dc.contributor.authorSukhodub, L. F.
dc.contributor.authorMamalis, A. G.
dc.contributor.authorLavrynenko, S. N.
dc.contributor.authorRamsden, Jeremy J.
dc.date.accessioned2010-02-01T15:09:35Z
dc.date.available2010-02-01T15:09:35Z
dc.date.issued2009-09
dc.description.abstractA series of biocompatible chitosan/hydroxyapatite composites has been synthesized in an aqueous medium from chitosan solution and soluble precursor salts by a one-step coprecipitation method. The composite materials were produced in dense and porous variants. XRD and IR studies have shown that the apatite crystals in the composites have structural characteristics similar to those of crystals in biogenic apatite. A study of in vivo behaviour of the materials was carried out. Cylindrical rods made of the chitosan/ hydroxyapatite composite material were implanted into the tibial bones of rats. After 5, 10, 15 and 24 days of implantation, histological and histo-morphometric analyses of decalcified specimens were undertaken to evaluate their biocompatibility and the possibility to apply them in bone tissue engineering. The calcified specimens were examined by scanning electron microscopy combined with X-ray microanalysis to compare the elemental composition and morphological characteristics of the implant and the bone during integration. Porous specimens were osteoconducting and were replaced in vivo by newly formed bone tissue.en_UK
dc.identifier.citationS.N. Danilchenko, O.V. Kalinkevich, M.V. Pogorelov, A.N. Kalinkevich, A.M. Sklyar, T.G. Kalinichenko, V.Y. Ilyashenko, V.V. Starikov, V.I. Bumeyster, V.Z. Sikora, L.F. Sukhodub, A.G. Mamalis, S.N. Lavrynenko and J.J. Ramsden. Chitosan–hydroxyapatite composite biomaterials made by a one step co-precipitation method: preparation, characterization and in vivo tests, Journal of Biological Physics and Chemistry, Vol.9, No.3, 2009, p.119-126en_UK
dc.identifier.issn1512-0856
dc.identifier.urihttp://hdl.handle.net/1826/4216
dc.language.isoenen_UK
dc.publisherCollegium Basilea & AMSIen_UK
dc.relation.ispartofwww.amsi.ge/jbpc
dc.subjectbiodegradationen_UK
dc.subjectchitosanen_UK
dc.subjecthydroxyapatiteen_UK
dc.subjectosteogenesisen_UK
dc.subjectscaffoldsen_UK
dc.titleChitosan–hydroxyapatite composite biomaterials made by a one step co-precipitation method: preparation, characterization and in vivo testsen_UK
dc.typeArticleen_UK

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