Three-dimensional numerical simulation of a failed coronary stent implant at different degrees of residual stenosis. Part II: Apparent viscosity and wall permeability

Abstract

The influence of the degree of residual stenosis (DOR) on the hemodynamics inside coronary arteries is investigated through three-dimensional (3D) numerical simulations. The vascular wall permeability is investigated and the effect of the non-Newtonian viscosity discussed. The results agree in predicting an abrupt increase in wall permeability above 45% DOR, indicating that the implant could lead to a massive restenosis. This behavior is considered to be due to the shift of the regions involved by low and oscillatory wall shear stress (WSS), from the zone adjacent to the struts toward the center of the stent meshes.