Taurine reprograms mammary-gland metabolism and alleviates inflammation induced by Streptococcus uberis in mice

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dc.contributor.authorLan, Riguo
dc.contributor.authorWan, Zhixin
dc.contributor.authorXu, Yuanyuan
dc.contributor.authorWang, Zhenglei
dc.contributor.authorFu, Shaodong
dc.contributor.authorZhou, Yuanyuan
dc.contributor.authorLin, Xinguang
dc.contributor.authorHan, Xiangan
dc.contributor.authorLuo, Zhenhua
dc.contributor.authorMiao, Jinfeng
dc.contributor.authorYin, Yulong
dc.date.accessioned2021-06-21T10:58:44Z
dc.date.available2021-06-21T10:58:44Z
dc.date.issued2021-06-10
dc.description.abstractStreptococcus uberis (S. uberis) is an important pathogen causing mastitis, which causes continuous inflammation and dysfunction of mammary glands and leads to enormous economic losses. Most research on infection continues to be microbial metabolism-centric, and many overlook the fact that pathogens require energy from host. Mouse is a common animal model for studying bovine mastitis. In this perspective, we uncover metabolic reprogramming during host immune responses is associated with infection-driven inflammation, particularly when caused by intracellular bacteria. Taurine, a metabolic regulator, has been shown to effectively ameliorate metabolic diseases. We evaluated the role of taurine in the metabolic regulation of S. uberis-induced mastitis. Metabolic profiling indicates that S. uberis exposure triggers inflammation and metabolic dysfunction of mammary glands and mammary epithelial cells (the main functional cells in mammary glands). Challenge with S. uberis upregulates glycolysis and oxidative phosphorylation in MECs. Pretreatment with taurine restores metabolic homeostasis, reverses metabolic dysfunction by decrease of lipid, amino acid and especially energy disturbance in the infectious context, and alleviates excessive inflammatory responses. These outcomes depend on taurine-mediated activation of the AMPKā€“mTOR pathway, which inhibits the over activation of inflammatory responses and alleviates cellular damage. Thus, metabolic homeostasis is essential for reducing inflammation. Metabolic modulation can be used as a prophylactic strategy against mastitis.en_UK
dc.identifier.citationLan R, Wan Z, Xu Y, et al., (2021) Taurine reprograms mammary-gland metabolism and alleviates inflammation induced by Streptococcus uberis in mice. Frontiers in Immunology, Volume 12, June 2021, Article number 696101en_UK
dc.identifier.issn1664-3224
dc.identifier.urihttps://doi.org/10.3389/fimmu.2021.696101
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/16791
dc.language.isoenen_UK
dc.publisherFrontiersen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectmastitisen_UK
dc.subjectStreptococcus uberisen_UK
dc.subjecttaurineen_UK
dc.subjectmetabolic regulationen_UK
dc.subjectAMPKen_UK
dc.subjectmTORen_UK
dc.titleTaurine reprograms mammary-gland metabolism and alleviates inflammation induced by Streptococcus uberis in miceen_UK
dc.typeArticleen_UK

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