Mid-IR spectroscopic instrumentation for point-of-care diagnosis using a hollow silica waveguide gas cell

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dc.contributor.authorFrancis, Daniel
dc.contributor.authorHodgkinson, Jane
dc.contributor.authorWalton, Christopher
dc.contributor.authorSizer, Jeremy
dc.contributor.authorBlack, Paul
dc.contributor.authorLivingstone, Beth
dc.contributor.authorFowler, Dawn P.
dc.contributor.authorPatel, Mitesh K.
dc.contributor.authorTatam, Ralph P.
dc.date.accessioned2017-06-22T10:51:09Z
dc.date.available2017-06-22T10:51:09Z
dc.date.issued2017-02-17
dc.description.abstractLaser spectroscopy provides the basis of instrumentation developed for the diagnosis of infectious disease, via quantification of organic biomarkers that are produced by associated bacteria. The technology is centred on a multichannel pulsed quantum cascade laser system that allows multiple lasers with different wavelengths to be used simultaneously, each selected to monitor a different diagnostic biomarker. The instrument also utilizes a hollow silica waveguide (HSW) gas cell which has a very high ratio of interaction pathlength to internal volume. This allows sensitive detection of low volume gas species from small volume biological samples. The spectroscopic performance of a range of HSW gas cells with different lengths and bore diameters has been assessed using methane as a test gas and a best-case limit of detection of 0.26 ppm was determined. The response time of this cell was measured as a 1,000 sccm flow of methane passed through it and was found to be 0.75 s. These results are compared with those obtained using a multi-pass Herriot cell. A prototype instrument has been built and approved for clinical trials for detection of lung infection in acute-care patients via analysis of ventilator breath. Demonstration of the instrument for headspace gas analysis is made by monitoring the methane emission from bovine faeces. The manufacture of a hospital-ready device for monitoring biomarkers of infection in the exhaled breath of intensive care ventilator patients is also presented.en_UK
dc.identifier.citationDaniel Francis, Jane Hodgkinson, Christopher Walton, Jeremy Sizer, Paul Black, Beth Livingstone, Dawn P. Fowler, Mitesh K. Patel and Ralph P. Tatam. Mid-IR spectroscopic instrumentation for point-of-care diagnosis using a hollow silica waveguide gas cell. Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics. Photonics West, 27 January - 1 February 2017, San Francisco, CA, USA.en_UK
dc.identifier.issn0277-786X
dc.identifier.urihttp://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=2605726
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/12095
dc.language.isoenen_UK
dc.publisherInternational Society for Optics and Photonics - SPIEen_UK
dc.rights©2017 SPIE. Please refer to any applicable publisher terms of use.
dc.subjectMid-infrareden_UK
dc.subjectspectroscopyen_UK
dc.subjectquantum cascade laseren_UK
dc.subjecthollow silica waveguideen_UK
dc.subjectbiomarkeren_UK
dc.subjectvolatile organicen_UK
dc.subjectdiagnosticsen_UK
dc.subjectheadspaceen_UK
dc.subjectpoint-of-careen_UK
dc.titleMid-IR spectroscopic instrumentation for point-of-care diagnosis using a hollow silica waveguide gas cellen_UK
dc.typeConference paperen_UK

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